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Conversely, sacubitril/valsartan has been shown to increase PRA, ANG I and ANG II levels in a canine model of RAAS activation
Metabolic Signaling
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In contrast, PWA mice display overt metabolic perturbations, including overweight and impaired glucose homeostasis 46 , and may mimic the canonical human phenotype A of PCOS linked to hyperandrogenism, anovulatory cycles, and polycystic ovarian morphology 45
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